Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers

Background: Measures of spatial intratumor heterogeneity are potentially important diagnostic biomarkers for cancer progression, proliferation, and response to therapy.Spatial relationships among cells including cancer and stromal cells in the tumor microenvironment (TME) are key contributors to heterogeneity.Methods: We demonstrate how to quantify

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THE IMPACT OF FERTILIZATION AND FOLIAR STIMULATION PRODUCTS BOTH ON INCREASING THE RESISTANCE TO MAJOR PHYTOPATHOGENS ATTACKS, AND ON INCREASING THE QUANTITY AND QUALITY OF WINE GRAPES HARVEST

The paper aimed to demonstrate the impact of fertilization and foliar stimulation products both Face Mask on increasing the resistance to major phytopathogens attacks, and on increasing the quantity and quality of wine grapes harvest.Applying the foliar fertilizer products Plonvit Kali (c1), Tytanit (c2) and Optysil (c3) to vines, for a period of t

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Comparing Tribochemical Film Formation and Durability at Steel and CrN Coating Interface in Boundary Lubrication

One of the main challenges that engine oil manufacturers are now facing is to reduce friction losses while at the same time increasing the durability of engine components.New materials are being used for engine components, alongside and to replace conventional ferrous materials.More components Spa Chemicals are being coated with low friction and hi

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